Conference Speakers
Paul Buehler PharmD, PhD
Professor of Pathology & Pediatrics, Principle Investigator, Center for Blood Oxygen Transport and Hemostasis University of Maryland
Dr. Buehler is a pharmacologist and toxicologist who utilizes both applied and mechanistic approaches to understand red blood cell hemolysis and the downstream effects extracellular hemoglobin, heme and iron toxicity. His work focuses on genetic/acquired anemias as well as toxin and mechanical device induced hemolysis to characterize the genomic and proteomic changes in tissue that preempt or coincide with pathology. This work has led to significant discoveries related to toxicant induced red blood cell damage following intravenous abuse of Opana ER. This collaborative work with FDA has contributed to the recall of the deterrent formulated opiate, Opana ER (Oxymorphone HCl extended release) after a shift toward greater intravenous abuse and subsequently increased clinical cases of thrombotic microangiopathy and hemolytic uremic syndrome.
